2024 Scientific Program
SUNDAY, 19 May, 2024
7:30 am- Registration
8:30 am Welcome and Announcements
9:00-10:00 am Session #1 “Descending Modulation and Pain” Kirsty Bannister (Chair)
• Patrik Ernfors (Karolinska Institutet, Sweden) “The neurons of morphine antinociception”
• Diana Torta (KU Leuven, Belgium) “Psychophysiology of top-down modulation of secondary mechanical hyperalgesia: what do we know so far?”
• David Finn (University of Galway, Ireland) “The impact of stress and negative affect on pain: role of the endocannabinoid system”
• Tony Pickering (University of Bristol, UK) “Evolution of noradrenergic neuromodulation : what if the modules compete amongst themselves?”
10:00 - 10:45 am Coffee break
10:45- 11:30 am Data blitz #1 Kirsty Bannister (Chair)
• Michelle Roche (University of Galway, Ireland) “Neurobiology underlying altered nociception and pain in autism”
• Simon d’Aquin (University of Zurich, Switzerland) “Descending pain modulation by corticospinal S1 neurons”
• Jordan McCall (Washington University in St. Louis, USA) “Endogenous opioid regulation of locus coeruleus-mediated analgesia”
• Robbie Drake (Bristol University, UK) “Assessing cortical-midbrain interactions with oxygen amperometry for improved translation of fundamental pain research”
• Xiaoke Chen (Stanford University, USA) “A closed-loop circuits for chronic mechanical pain”
• Charlotte Lawrenson (Exeter University, UK) “Susceptibility to chronic pain: role of cerebellar-midbrain interactions”
11:30 – 12:30 pm Session #2 “Sensory Neurons and Pain” Greg Weir (Chair)
• Steve Middleton (University of Oxford, UK) “Silencing sensory neurons in rodent and human pain models”
• George Goodwin (King's College London, UK) “Large-scale examination of spontaneous sensory neuron activity in models of pain using in vivo calcium imaging”
• Stefan Lechner (University Medical Center Hamburg-Eppendorf, Germany) “The role of silent nociceptors in inflammatory pain”
• Greg Weir (University of Glasgow, UK) “Determining the contribution of discrete sensory neuron types to neuropathic pain”
12:30 - 2:00 pm Free for Lunch
2:00 - 3:00 pm Session #3 "Sensory Neurons and Pain” Alex Binshtok (Chair)
• Alex Binshtok (The Hebrew University of Jerusalem, Israel) "Spatial and temporal integration of pain-related signals along nociceptive terminals"
• Armen Akopian (University of Texas Health Science Center at San Antonio, USA) “Identity and function of sensory neurons controlling facial myalgia”
• Seog Bae Oh (Seoul National University, South Korea) “Natural Killer Cells as a novel therapeutic target for neuropathic pain”
• Michaela Kress - (Medical University Innsbruck, Austria) "IL-4 shaping glutamatergic synapse-like structures for more mature human iPSC-derived neuronal phenotypes"
3:00- 3:30 pm Data Blitz #2 “Sensory Neurons and Pain” Alex Binshtok (Chair)
• Pascal Fossat (University of Bordeaux, France) “Spinal cord electrophysiology in freely-moving mice”
• Sara E. Jager (Copenhagen University, Copenhagen, Denmark) “Investigating network patterns of sensory signalling in the rat spinal cord”
• Javier López Soto (North Carolina State University , USA) "Nociceptor function through cell-specific alternative splicing"
• Stuart Bevan (King’s College London, UK) “Pain in Post-COVID syndrome patients”
3:30 – 4:15 pm Coffee break
4:15- 5:15 pm Session #4 "The Microbiome and Pain" Kate Sadler (Chair)
• Kate Sadler (University of Texas at Dallas, USA) “The gut microbiome and gastrointestinal chemosensation drive chronic sickle cell disease pain”
• Christophe Altier (University of Calgary, Canada) “Early life microbiota colonization programs nociceptor sensitivity via mast cell-derived NGF”
• Arkady Khoutorsky (McGill University, Canada) “Gut microbiota promotes pain in fibromyalgia”
• Anna Taylor (University of Alberta, Canada) “Targeting the gastrointestinal environment as a treatment for opioid induced hyperalgesia”
5:15 – 6:30 pm – Data Blitz #3 Kate Sadler (Chair)
• Elena Lucarini (University of Florence, Italy) "Mechanistic insight into the interplay between gut and microbiota responsible for the persistence of post-inflammatory visceral pain"
• Steven Prescott (Hospital for Sick Children & University of Toronto, Canada) ”Automated pain testing in mice using robotics and machine learning”
• Shivani Ruparel (University of Texas San Antonio, USA) “Beyond rodents; exploring pain with the uncommon Common Marmoset”
• Laurent Martin (Southern Arizona VA Health Care System, Tucson, USA) “Phototherapy to modulate human sensory thresholds’
• Nikita Ruparel (University of Texas Health Science Center at San Antonio, USA) "The emerging role of macrophage migration inhibitory factor in orofacial pain"
• Qiufu Ma (Westlake University, Hangzhou, Zhejiang, China) “A blockage of incision pain development by electroacupuncture”
• Jackson Brougher (Doloromics Inc, Menlo Park, USA) “Negative allosteric modulation of GPCRs in spinal projection cells and interneurons”
• Ben Title (The Hebrew University of Jerusalem, Israel) “The Guardians of Passage: adaptive changes in the output from the first nociceptive neural network”
• David Zimmermann (Medical University of Innsbruck, Austria) "Biophysical Essentials; a full stack open-source software framework for conserved and advanced analysis of patch-clamp recordings”
6:45 -7:45 pm Aperitivo (get-together in the main lobby at ground level, with food and drink)
MONDAY, 20 May, 2024
8:30- 9:30 am Session #5 “Keratinocytes and Pain” Cheryl Stucky (Chair)
• Matthieu Talagas (University of Western Brittany and Brest University Hospital, Brest, France) “Neuro-keratinocyte synapses”
• Stephanie Puig (University of Massachusetts, USA) “Involvement of keratinocytes and platelet-derived growth factor receptor signaling in peripheral opioid tolerance”
• Daniela Maria Menichella (Northwestern University, USA) “Non-neuronal cells and cutaneous afferent communication in painful diabetic neuropathy”
• Nurcan Üçeyler (University Hospital Würzburg, Germany) “The Neuro-cutaneous Unit; the role of skin in pain”
9:30-10:15 am Data blitz #4 Cheryl Stucky (Chair)
• Diana Bautista (UC Berkeley, USA) “Neurocutaneous plasticity after spinal cord injury”
• Michael Caterina (Johns Hopkins School of Medicine, USA) “Pain mechanisms in hereditary skin diseases”
• Cheryl Stucky (Medical College of Wisconsin, USA) “Keratinocytes actively drive input for neuropathic pain”
• Alfonso Romero-Sandoval (Wake Forest University School of Medicine, USA) “ER stress in immune cells in the context of CIPN”
• Hanneke Willemen (UMC Utrecht, The Netherlands) "Metabolic disturbances in sensory neurons predispose to the transition from acute to chronic pain"
• Samiha Shaikh (University of Cambridge, UK) “Unravelling Genetic Predisposition in Complex Regional Pain Syndrome Type 1”
10:15 - 11:00 am Coffee break
11:00 am - 12:00 pm Session #6 “GPCR Signaling and Beyond” Daniela Salvemini/Andrea Hohmann (Co-Chairs)
• Andrea Hohmann (Indiana University Bloomington, USA) “A brain impermeant inhibitor of monoacylglycerol lipase suppresses neuropathic pain through a CB2 receptor mechanism without producing tolerance or physical dependence”
• Daniele Piomelli (University of California Irvine, USA) “A lipid signaling mechanism that gates the progression to pain chronicity”
• Amynah Pradhan (Washington University, St. Louis, USA) “Delta opioid receptors as a therapeutic target for headache disorders”
• Daniela Salvemini (St. Louis University School of Medicine, USA) “Spinal roles of the GPCR P2Y14 in neuropathic pain”
• Jason McDougall (Dalhousie University, Halifax, Canada) “Protease activated receptors and arthritis pain”
12:00-12:30 pm Data Blitz #5 Jeffrey Mogil (Chair)
• Venetia Zachariou (Boston University, USA) “Modulation of sensory hypersensitivity by G protein complexes in models of neuropathic pain”
• Catherine Cahill (UCLA, USA) “Chronic pain enhances acquisition of remifentanil self-administration in a sex dependent manner”
• Lucia Hipolito (University of Valencia, Spain) “Previous exposure to morphine self-administration prevents pain-induced increase of alcohol intake in female rat”
• Martin Löffler (Heinrich Heine University Düsseldorf, Germany) “Learning-related neural predictors of the development and treatment of chronic pain”
12:30 - 2:00 pm Free for Lunch
2:00 - 3:00 pm Session #7 “Sex Differences and Pain” Jeffrey Mogil (Chair)
• Jeffrey Mogil (McGill University, Montreal, Canada) “Pain, Sex, and Pavlov’s Dog”
• Jose Moron-Concepcion (Washington University, St. Louis, USA) “Sex-specific effects of pain on fentanyl self-administration and the role of ovarian hormones”
• Joyce T. Da Silva (University of Maryland, Baltimore, USA) “Sex differences in pain and treatment outcomes: a whole-brain functional MRI analysis”
• Michael W. Salter (University of Toronto, Canada) “Sex differences, and similarities, in a model of peripheral neuropathic pain”
3:00- 4:00 pm Session #8 “Transition from Acute to Chronic Pain” Susanne Becker (Chair)
• Emanuel van den Broeke (KU Leuven, Health Psychology, Belgium) “Is the susceptibility to develop central sensitization predictive for persistent post-surgical pain?”
• Susanne Becker (Heinrich Heine University Düsseldorf, Germany) “Psychobiological mechanisms of the intersection of reward and pain processing; a route to chronic pain?”
• Anne-Marie Heegaard (University of Copenhagen, Denmark) “Pain in malignant and non-malignant bone disorders”
• Chelsea Hopkins (University of Copenhagen, Denmark) “Pain in Fibrous Dysplasia; identifying nociceptive mechanisms in a preclinical model”
4:00- 4:45 pm Coffee break
4:45- 5:45 pm Session #9 “Pain in Development” Maria Fitzgerald (London, UK, Chair)
• Simon Beggs (Inst Child Health, London, UK) “The impact of early life injury on social behaviour”
• Rebeccah Slater (Univ. of Oxford, UK) “Developing pain vulnerability in early life”
• Lorenzo Fabrizi (UCL, London, UK) “Maturation of cortical pain processing in preterm infants”
• Artur Kania (McGill Univ, Montreal, Canada) “Developmental insights into the function of spinal projection neurons”
5:45- 6:05 pm Data blitz #6 Maria Fitzgerald (Chair)
• Judy Yoo (University of Cincinnati, USA) “Early life injury alters spinal astrocyte development”
• Stephanie Koch (UCL, London, UK) “Plasticity in sensorimotor circuits”
• Nynke van den Hoogen (University of Calgary, Canada) “Neonatal pain and opioids; life-long effects on nociception”
TUESDAY, 21 May, 2024
8:30- 9:30 am Session #10 “Human Nociceptor Physiology, Pathology, and Signaling” Ted Price (Chair)
• Rob Gereau (Washington University School of Medicine, St. Louis, USA) “Human nociceptor physiology and patch-seq”
• Angelika Lampert (RWTH Aachen University, Germany) “A molecular marker for human sleeping nociceptors determined by Patch-Seq”
• Heike Rittner (University Hospital Wuerzburg, Germany) “Neuronal pathology in the human DRG after brachial avulsion and its relation to pain”
• Patrick Dougherty (University of Texas MD Anderson Cancer Center, USA) “Mechanisms of spontaneous activity in human nociceptors”
9:30- 10:30 am Session #11 “Insights into Pain Mechanisms from Studies of Human Tissue” Rob Gereau (Chair)
• Will Renthal (Harvard Medical School, USA) “Harmonized cross-species atlases of trigeminal and dorsal root ganglia"
• Esther Pogatzki-Zahn (University Muenster, Germany) “Human skin and blood proteomics after incision/postsurgical pain”
• Steve Davidson (University of Cincinnati, USA) “GPCR signaling in human nociceptors”
• Diana Tavares-Ferreira (University of Texas at Dallas, USA) “mRNA localization in human peripheral axons”
10:30 - 11:15 am Coffee break
11:15-12:30 pm Data Blitz #7 “Insights into Pain Mechanisms from Studies of Human Tissue” Rob Gereau (Chair)
• Ted Price (University of Texas at Dallas, USA) “Molecular pathology in the human DRG linked to diabetic neuropathic pain”
• Jimena Perez-Sanchez (University of Oxford, UK) “Assessing neuropathic changes in primary afferent excitability using human iPSC-derived nociceptors”
• Harrison Stratton (University of Arizona and University of Pittsburgh, USA) “Sexual dimorphism in human nociceptors”
• Deborah Schechtman (University of São Paulo, Brazil) "Exploring phospholipase C gamma as a key player in inflammatory pain"
• Martina Morchio (University of Sheffield, UK) "Molecular changes linked with neuropathic pain in human lingual neuromas"
• Behrang Sharif (McGill University, Montreal, Canada) “Cellular heterogeneity in human DRGs: what do we learn from ATAC and Long-Read sequencing”
12:30 - 2:00 pm Free for Lunch
2:00 - 3:00 pm Session #12 “Visceral Pain Mechanisms” Nick Spencer and Stuart Brierley (Co-Chairs)
• Lori Birder (University of Pittsburgh, USA) “PNPase inhibition- an effective approach for the treatment of visceral pain”
• Edita Navratilova (University of Arizona, USA) “Mechanisms of endometrial pain”
• David Bulmer (University of Cambridge, UK) “GPR35 as a target for the treatment of visceral pain”
• Nicolas Cenac (Inserm UMR1220 Digestive Health Research Institute, Toulouse, France) “Microbiota-sensory nerve interactions: towards mechanisms in visceral pain”
3:00 - 3:45 Data Blitz #8 Nick Spencer and Stuart Brierley (Co-Chairs)
• Nathalie Vergnolle (INSERM U1220 Digestive Health Research Institute, Toulouse, France) “Epithelial signals in pain associated with inflammatory bowel diseases”
• James Bayrer (University of California San Francisco, USA) “Gut sensory epithelial cells modulate visceral pain”
• Ursula Wesselmann (University of Alabama at Birmingham, USA) “Translational opportunities; chronic visceral pain syndromes in the context of co-morbid pain conditions”
• Stuart Brierley (South Australian Health and Medical Research Institute, Australia) “New aspects on the mechanisms underlying chronic visceral pain”
• Nick Spencer (Flinders University, Australia) “Does the vagus nerve encode visceral pain signals from lower abdominal organs?”
3:45-4:30 pm Coffee break
4:30-5:30 pm Session #13 “Osteoarthritis/Joint Pain” Ewan St. John Smith (Chair)
• Eva Kosek (Karolinska Institutet, Stockholm, and Uppsala University, Sweden) “The neuroimmune interface in OA pain"
• Niels Eijkelkamp (University Medical Center Utrecht, Netherlands) “Targeting the immune system to control OA pain”
• Rachel Miller (Rush University Medical Center, Chicago, USA) “Mechanical aspects of osteoarthritis pain”
• Ewan St. John Smith (University of Cambridge, UK) “Driving and controlling joint pain”
5:30-6:30 pm Data Blitz #9 - Ewan St. John (Chair):
• David Walsh (University of Nottingham, UK) “OA pain: mechanisms informing symptoms”
• Jason Ivanusic (University of Melbourne, Australia) “Neural mechanisms of bone pain; tools for exploring the structure and function of nerves in bone”
• Shao-Jun Tang (Stony Brook University, USA) “Pathogenic mechanism of HIV-associated pain”
• Nils Simon (Karolinska Institutet, Stockholm, Sweden) “Characterization of the antinociceptive effect of baricitinib in the collagen antibody-induced arthritis mouse model”
• Sophie Pezet (Laboratory ‘Physics for Medicine’, INSERM, ESPCI-PSL, France) “New insights in migraine physiopathology using ultrafast ultrasound imaging”
• Anne Baron (IPMC, Université Cote d'Azur, Sophia Antipolis, France) "Decreased expression of phosphodiesterase 2A rescues inflammatory cutaneous hypersensitivity defect associated with autism spectrum disorders and intellectual disability in a mice model of Fragile X Syndrome"
• Earl Carstens (University of California, Davis, USA) "Role of substance P in descending modulation of itch and pain"
• Manuela Schmidt (University of Vienna, Austria) “Proteome-based systems biology to explore age and sex differences in neuropathic pain”
WEDNESDAY, 22 May, 2024
8:30-9:30 am Session #14 "The NaV1.7 Dilemma; To Target or Not to Target, That is the Question" Rajesh Khanna (Chair)
• David Bennett (University of Oxford, UK) "Genetic basis of inherited painful channelopathies"
• Sulayman Dib-Hajj (Yale University, USA) "Spatial and temporal regulation of Nav1.7 channels in sensory neurons by inflammatory mediators"
• Rajesh Khanna (University of Florida, USA) "NaV1.7 under siege: CRMP2-Ubc9 inhibition shines as the promising path to pain relief"
• Irina Vetter (University of Queensland, Australia) "Pain-causing Stinging Nettle toxins target TMEM233 to modulate NaV1.7 function"
9:30-10:30 am Session #15 - "Sodium Channels and Pain" - John Hunter (Chair)
• John Mulcahy (SiteOne, USA) "Nav1.7 state-independent inhibitors: translation of preclinical findings to the clinic"
• David Hackos (Genentech, USA) “Nav1.7 inhibitors in the clinic: what we've learned, why it's hard, and the path forward”
• Darrell Henze (Merck & Co., Inc., Rahway, NJ, USA) "Clinical dose prediction and MOA studies for Nav1.8 inhibitors to treat pain"
• John Hunter and Darrell Henze (SiteOne, USA and Merck & Co., Inc., Rahway, NJ, USA) "Selective Nav1.8 inhibitors for the treatment of pain"
10:30 - 11:15 am Coffee break
11:15-12:15 pm Session #16 Neuroimmune Axis and Pain Shafaq Sikandar (Chair)
• Thiago Cunha (Center for Research in Inflammatory Diseases CRID- University of Sao Paulo, Brazil) “Meningeal innate lymphocyte ILC-2 drives neuropathic pain”
• Iain Chessell (AstraZeneca, UK) “Efficacy and safety of MEDI7352, an anti-NGF, anti-TNF bispecific in painful diabetic neuropathy”
• Luda Diatchenko (McGill University, Canada) “Contribution of neutrophils to fibromyalgia and other chronic pain conditions”
• Camilla Svensson (Karolinska Institutet, Sweden) “Neuroimmune interactions in the skin and DRG in fibromyalgia”
12:15 – 12:30 pm – Data blitz #10
• Margot Maurer (King’s College London, UK) “Immune contribution to pathological pain mechanisms in fibromyalgia”
• Zerina Kurtovic (Karolinska Institutet, Sweden) “Exploring novel macrophage and neutrophil-associated mechanisms in autoantibody-induced pain”
12:30 - 2:00 pm Free for Lunch
2:00 – 3:00 pm Session #17 “Neuroimmune Axis and Pain” Camilla Svensson (Chair)
• Shafaq Sikandar (Queen Mary University of London, UK) “Immunological basis of nociplastic pain states”
• Mathilde Israel (King’s College London, UK) “Sensory afferent abnormalities in passive-transfer of fibromyalgia”
• Sebastien Talbot (Queen’s University, Canada; Karolinska Institutet, Sweden) “Opioid-producing B-cells silence tumor-infiltrating neurons
• Javier Aguilera-Lizarraga (University of Cambridge, UK) “Neuroimmune interactions triggered by psychological stress lead to food-induced abdominal pain”
3:00-4:00 pm Session #18 “Cortical Circuits and Pain I” Jing Wang (Chair)
• Jing Wang (New York University, USA) “Cortical mechanisms and neuromodulation”
• Markus Ploner (Technical University of Munich, Germany) “Neuronal oscillations and connectivity in human pain processing”
• Patrick Sheets (Indiana University, USA) “Dissecting cellular-circuit disruption of defined mPFC neurons in mouse models of pain”
• Gerald Zamponi (University of Calgary, Canada) “Optogenetic dissection of neocortical pain pathways”
4:00-4:45 pm Coffee Break
4:45-6:15 pm Session #19 “Cortical Circuits and Pain II” Rohini Kuner (Chair)
• Rohini Kuner (Heidelberg University, Germany) “Exploiting neocortical circuits for pain relief”
• Carl Saab (Cleveland Clinic, USA) “From ocular pain in mice to personalized pain medicine and AI: A translational journey”
• Philippe Séguéla (McGill University, Canada) “New insights on dysregulated dopaminergic signaling in neuropathic ACC”
• Thomas Nevian (University of Bern, Switzerland) “Cortical signatures of analgesia”
• Min Zhuo (University of Toronto, Canada) “LC-ACC-spinal connections in pain”
• Vania Apkarian (Northwestern University, USA) “Neuropsychology of long-term opioid exposure in chronic pain”
THURSDAY, 23 May, 2024
8:30-9:30 am Session #20 “Amygdala and Pain I Volker Neugebauer (Chair)
• Yarimar Carrasquillo (National Institutes of Health, Bethesda, USA) “Divergent amygdala circuits for somatosensory and affective components of pain”
• Greg Scherrer (University of North Carolina, Chapel Hill, USA) “Neural circuits and therapeutics for pain unpleasantness and its cognitive modulation”
• Fan Wang (McGovern Institute, MIT, Cambridge, USA) “Amygdala control of the emotional aspect of pain”
• Fusao Kato (Jikei University School of Medicine, Tokyo, Japan) “Attempt to whole-brain visualization of pain-associated neurons and their networks”
9:30- 10:30 am Session 21: Amygdala and Pain II Yarimar Carrasquillo (Chair)
• Ipek Yalcin (CNRS, University of Strasbourg, France) “Cingulate cortex; crossroads between amygdala and habenula”
• Shashank Dravid (Texas A&M University, USA) “Glutamate delta 1 and autophagy mechanisms in the central amygdala in chronic pain”
• Gregory Corder (University of Pennsylvania, USA) “Nociceptive amygdala-striatal circuits for pain aversion”
• Marta Ceko (University of Colorado Boulder, USA) “Distributed processing of pain and negative affect in the human brain"
10:30 - 11:15 am Coffee break
11:15 - 12:00 pm Data Blitz #11 “Amygdala and Pain” Volker Neugebauer (Chair)
• Volker Neugebauer (Texas Tech University Health Sciences Center, Lubbock, USA) “Amygdala neuroplasticity and neuroimmune signaling”
• Guangchen Ji (Texas Tech University Health Sciences Center, Lubbock, USA) “Opposing functions of mu and kappa opioid receptor neurons in the amygdala in neuropathic pain”
• Benedict Kolber (University of Texas at Dallas, USA) ”The surprising impact of CGRP in the amygdala in different pain models”
• Nick Gilpin (LSUHSC, New Orleans, USA) “Chronic alcohol produces long-term hyperalgesia associated with amygdala circuit function”
• Mike Burman (University of New England, USA) “Sex-dependent changes in central nucleus of the amygdala neuropeptide expression following early-life pain”
12:00 - 12:30 pm Data Blitz #12
• Dale George (Doloromics Inc, Menlo Park, USA) “Identification of a high-affinity mTOR binder leading to specific protein degradation and reduced neuronal excitability”
• Letizia Marvaldi (Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy) “Importin alpha3 controls age-dependent axonal branching by modulating ribosomal protein expression”
• Ichrak Drissi (University of Cambridge, UK) “Congenital insensitivity to pain or Midface Toddler Excoriation Syndrome? A matter of PRDM12 polyalanine tract expansion”
• Andrea Furlan (University of Toronto, Canada) “Results of a randomized controlled trial of opioid tapering for chronic pain”
12:30 - 2:00 pm Free for Lunch
2:00 - 3:00 pm Session #22 Spinal and Ascending Brain Circuits” Reza Sharif (Chair)
• Allan Basbaum (University of California San Francisco, USA) “Anesthetized vs. awake recording provides a new view of the labeled line question”
• Sam Myung-chul Noh (University of Pittsburgh, USA) “Mechanical allodynia circuitry within a cross species, cell type atlas for therapeutic applications”
• Charles Warwick (University of Pittsburgh, USA) “A population view of somatosensory integration”
• Andrew Bell (University of Glasgow, UK) “Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons”
3:00 – 4:00 pm Session #23 "Spinal Circuits” David Hughes (Chair)
• Reza Sharif (McGill University, Canada) "Defective maturation of spinal circuits for touch and pain in Christianson Syndrome”
• David Hughes (University of Glasgow, UK) “Presynaptic control of C-fibre low-threshold mechanoreceptor afferents”
• Mark Gradwell (Rutgers University, USA) “Tactile sensitivity scaling by the dorsal column nuclei"
• Martyn Goulding (Salk Institute, USA) "Mechanical allodynia: the dorsal column nuclei revisited"
4:00 - 4:45 pm Coffee break
4:45 - 5:45 pm Session #24 “Neuropeptides and Pain” Marc Landry and Bradley Taylor (Co-Chairs)
• Debbie Hay (University of Otago, Dunedin, New Zealand) “Amylin and CGRP in migraine”
• Greg Dussor (University of Texas at Dallas, USA) “Peptides in the meninges; potential roles in migraine”
• Marc Landry (University of Bordeaux, CNRS , France) “Relaxin 3-mediated analgesia in ACC and BLA”
• Brad Taylor (University of Pittsburgh, USA) “NPY and Y1 receptors in parabrachial nucleus”
5:45- 6:30 pm Data blitz #13 Marc Landry (Chair)
• Nick Betley (University of Pennsylvania, USA) “A parabrachial hub for the prioritization of survival behavior”
• Carol Kopruszinski (University of Arizona, USA)/Tharani Chessell (AstraZeneca, UK) "PAR2 as a therapeutic target for migraine"
• Juliana Geremias Chichorro (Federal University of Parana, Brazil) "Contribution of Cav3.2 to migraine-related responses in vivo and in vitro"
• Daniel Castro (Washington University, St. Louis, USA) "Endogenous enkephalin peptide in dorsal raphe nucleus regulates aversion sensitivity"
• Dustin Green (University of Texas Medical Branch, Galveston, USA) “A role for MRGPRs in pain”
• Lauriane Delay (Physics for Medicine / NeuroDol, France) “Functional connectivity changes in preclinical models of migraine using a new approach of neuroimaging: functional ultrasound imaging”
FRIDAY, 24 May, 2024
8:30- 9:30 am Session #25 “What Brain Imaging Can Teach Us About Human Pain and Pain Modulation” - Marco Loggia (Chair)
• Luke Henderson (University of Sydney, Australia) “Human brainstem imaging of pain and pain modulation”
• Ulrike Bingel (University Medicine Essen, Germany) “Different mechanisms underlying placebo analgesia and translational implications”
• Karin Jensen (Karolinska Institutet, Stockholm, Sweden) “Brain representations of pain among individuals with self-injury behavior”
• Marco Loggia (Harvard Medical School and Massachusetts General Hospital, Boston, USA) “Pain, the pandemic, and brain inflammation”
9:30-10:15 am Data Blitz #14 Marco Loggia (Chair)
• Zeynab Alshelh (University of Sydney, Australia) "Can presurgical brain inflammation predict recovery from total knee replacement?"
• Joe Taylor (King's College London, UK) “Using functional MRI and psychophysics to investigate ascending and descending pain modulation pathways''
• Kevin Keay (University of Sydney, Australia) “Position-emission tomography imaging of glial reactivity in a preclinical model of orofacial neuropathic pain”
• Lewis Crawford (University of Sydney, Australia) “Assessing the behavioural consistency and neural activation of placebo analgesia responses across time"
• Andrew Marshall (University of Liverpool, UK) “Signaling of mechanical pain in the human anterolateral pathway”
10:15- 11:00 am – Coffee break
11:00- 12:00 pm Session #26 “Translational Challenges of Bringing Optogenetics to Pain Therapy” Marie-Eve Paquet (Chair)
• Oscar Solis (National Institute of Health, USA) “Optogenetic tools adapted to translational and future clinical applications”
• Marie-Eve Paquet (CERVO Brain Research Centre, Université Laval, Canada) “Challenges in viral-based gene transfer therapy for pain”
• Isabelle Aubert (Sunnybrook Research Institute, University of Toronto, Canada) “Focused ultrasound as a strategy for targeted gene delivery through the blood-brain barrier”
• Michael Joel Kessler (Trinity College, University of Toronto, Canada) “How to address life and personality-altering implications of optogenetics”
12:00- 12:30 pm Data Blitz #15 Marie-Eve Paquet (Chair)
• Aubin Moutal (St. Louis University, USA) “Space and time controlled gene editing to understand pain”
• Sanggon Kim (Université Laval, Canada) “Micro-lensed fiber optic probe for single cell optogenetics in vivo”
• Paschalina Chrysostomidou (University of Glasgow, UK) "Developing novel viral vectors to facilitate gene therapies for neuropathic pain"
12:30-2:00 pm Free for Lunch
2:00 - 3:00 pm Session #27 “Psychophysical Exploration of Pain” Kristian Petersen (Chair)
• Lucy Zhao (King's College London, UK) “Assessing pain and neurodiversity in persistent rheumatoid arthritis”
• Daniel Segelcke (University of Münster, Germany) “Advances in QST: bridging preclinical and clinical research for effective pain phenotyping”
• Laura Sirucek (Balgrist University Hospital, Zurich, Switzerland) “The association of pressure pain thresholds with periaqueductal gray neurotransmitters and its absence in chronic pain”
• Kristian Petersen (Aalborg University, Denmark) "Variability in QST findings and how we can utilize this in patients chronic pain"
3:00 – 3:30 pm Data Blitz #16 Kristian Petersen (Chair)
• Giulia Liberati (Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium) “Modulation of pain-related oscillations recorded from the human insula using intracerebral EEG”
• Thomas Graven-Nielsen (Aalborg University, Denmark) “The relevance of cortical homeostatic plasticity in the nociceptive system”
• Zachary Campbell (University of Wisconsin, USA) "The role of a conserved translation factor kinase in nociception"
3:30- 4:15 pm Coffee Break
4:15 -5:15 pm Session #28 “Mechanical Nociception” Saad Nagi (Chair)
• Wenqin Luo (University of Pennsylvania, USA) “Single-soma deep RNA-seq of human DRG neurons”
• Saad Nagi (Linköping University, Sweden) “Human Aβ-nociceptor subtypes and functions”
• Oumie Thorell (Western Sydney University, Australia and Linköping University, Sweden) "Pain and withdrawal reflex responses in humans"
• David Mahns (Western Sydney University, Australia) “Selective activation of human muscle spindle afferents; experimental and clinical studies”
5:15-6:15 pm Session #29 “Chloride-Gate; The Next Impeachment!” Yves De Koninck (Chair)
• Yves De Koninck (Université Laval, Québec, Canada) “KCC2, through the keyhole of the chloride-gate”
• Francesco Ferrini (Università degli Studi di Torino, Italy) “Chloride control: lady-gate vs. male-gate”
• Wendy Imlach (Monash University, Australia) “Chloride-gate across species”
• Shilpa Kadam, PhD (Axonis Therapeutics Inc., Boston, USA) “Targeting the chloride-gate for therapeutics”
END OF CONFERENCE
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